A rash, a fever, or feeling like you have the flu. The CDC lists fever as a symptom of every tickborne disease, along with headache, fatigue and muscle aches, and it notes that Lyme disease, Rocky Mountain spotted fever, ehrlichiosis and several others cause distinctive rashes. Rashes vary by disease and don't show up in everyone, so don't wait for one. The CDC's rule is simple: if you develop a rash or fever within several weeks of removing a tick, see your doctor and tell them when the bite occurred and where you likely picked up the tick. Don't wait for a rash to be sure; fever and aches after a known bite are enough.